How it may work
A diet-derived sulfur compound transported by OCTN1. Higher measured blood or plasma exposure does not establish target-tissue delivery, clinical benefit, disease prevention or finished-product bioavailability.
ระดับหลักฐานระดับหลักฐาน E
ดูบันทึกหลักฐานอิสระที่อธิบายด้วยภาษาที่เข้าใจง่าย ระดับหลักฐานแต่ละระดับตอบคำถามวิจัยที่กำหนดและไม่ใช่คะแนนของผลิตภัณฑ์
ทบทวนล่าสุด: 22 Aug 2026Why people are interested
A diet-derived sulfur compound transported by OCTN1. Higher measured blood or plasma exposure does not establish target-tissue delivery, clinical benefit, disease prevention or finished-product bioavailability.
Outcome map
One ingredient. Different questions.
Each row answers a separate question; evidence strength can differ by outcome.
- 01Level E
Human lifespan or validated healthspan
No completed human intervention reviewed demonstrated longer lifespan, validated healthspan, age reversal, disease prevention or treatment.
- 02Level B
Circulating exposure
Exact named oral preparations raised measured circulating exposure under tested conditions; this does not establish clinical efficacy or cross-source equivalence.
- 03Level C
Objective cognition
The human landscape is mixed and the largest completed trial was primary-null, so a reliable broad cognitive benefit has not been established.
- 04Level C
Subjective and objective sleep
Null global or intention-to-treat results coexist with isolated subscale, factor or exploratory EEG signals and do not establish a broad sleep benefit.
- 05Level E
Purified-material skin benefit
No adequate purified-material trial was identified, and whole-mushroom findings cannot be attributed to L-ergothioneine alone.
- 06Level B
Short-term tolerability
Selected adults showed no consistent serious product-attributed pattern under exact observed conditions; broader or long-term safety is not established.
What people have studied
Exact tested oral preparations increase measured circulating exposure, but exposure is not efficacy. The largest completed cognition trial was primary-null; positive cognition, sleep, skin and biomarker signals are exploratory, formulation-specific or limited by analysis-set, multiplicity, matrix and sponsor concerns. No completed human intervention demonstrates longer lifespan or validated healthspan.
What to consider
Selected short trials did not show a consistent serious product-attributed pattern under their exact conditions. They do not establish long-term, rare-event, interaction or vulnerable-population safety, and findings do not transfer across purified, fermented, mixed-extract, mushroom or finished-product sources.
Local pathway
This science review does not establish a Thailand market route. Ingredient source, process, specification and finished-product status require separate official confirmation.
แหล่งข้อมูล
แหล่งข้อมูล
ดูบันทึกหลักฐานอิสระที่อธิบายด้วยภาษาที่เข้าใจง่าย ระดับหลักฐานแต่ละระดับตอบคำถามวิจัยที่กำหนดและไม่ใช่คะแนนของผลิตภัณฑ์