How it may work
A naturally occurring polyamine involved in pathways including autophagy. Mechanistic plausibility does not show that a supplement extends life or improves validated healthspan.
ระดับหลักฐานระดับหลักฐาน E
ดูบันทึกหลักฐานอิสระที่อธิบายด้วยภาษาที่เข้าใจง่าย ระดับหลักฐานแต่ละระดับตอบคำถามวิจัยที่กำหนดและไม่ใช่คะแนนของผลิตภัณฑ์
ทบทวนล่าสุด: 22 Aug 2026Why people are interested
A naturally occurring polyamine involved in pathways including autophagy. Mechanistic plausibility does not show that a supplement extends life or improves validated healthspan.
Outcome map
One ingredient. Different questions.
Each row answers a separate question; evidence strength can differ by outcome.
- 01Level E
Human lifespan or validated healthspan
No completed human intervention reviewed demonstrated longer lifespan or an improvement in validated healthspan.
- 02Level C
Cognitive performance in older adults
A small imprecise pilot, a null largest 12-month trial and weaker active-control or uncontrolled designs leave the human landscape mixed.
- 03Level E
SmartAge primary memory endpoint
The prespecified primary result was null, so this exact regimen did not establish a positive memory effect.
- 04Level C
Dietary mortality association
Prospective cohorts associate higher estimated dietary intake with lower mortality, but association does not establish supplement efficacy or causation.
- 05Level B
Radiotherapy-associated xerostomia
One small trial reported less xerostomia at three months in this exact clinical context; it does not establish a general dry-mouth or longevity benefit.
- 06Level E
Long-term and complex-population safety
The reviewed short, selected studies do not establish long-term safety in the general population, pregnancy, cancer or complex polypharmacy.
What people have studied
Human evidence is heterogeneous and source-specific. Prospective cohorts associate higher dietary intake with lower mortality, but no completed intervention shows longer lifespan or healthspan. The largest 12-month cognition trial was null, a vaccine pilot produced only an exploratory selected-subgroup signal, and one small radiotherapy trial reported less xerostomia at three months.
What to consider
Selected short trials did not report a major treatment-related pattern under their exact conditions. They cannot establish broad or long-term safety, and wheat-germ extract, baked food, algae/soy, purified salt, diet and multi-ingredient preparations are not interchangeable.
Local pathway
This science review does not establish a Thailand market route. Ingredient source, formulation and finished-product status require separate official confirmation.
แหล่งข้อมูล
แหล่งข้อมูล
ดูบันทึกหลักฐานอิสระที่อธิบายด้วยภาษาที่เข้าใจง่าย ระดับหลักฐานแต่ละระดับตอบคำถามวิจัยที่กำหนดและไม่ใช่คะแนนของผลิตภัณฑ์