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Cell defence

Sulforaphane

Broccoli sprout isothiocyanate

Lifespan / validated healthspanEvidence level E

Level E marks a central question without dependable direct human evidence; read the outcome conclusion rather than treating the letter as a direction of effect.

This E grade answers the central longevity question only. Other outcomes are graded separately below.
REVIEWED EVIDENCE PACKETQuestion-specific review complete for this published scope.

The grade is controlled by the stated packet question and outcome map.

IN PLAIN LANGUAGE

Why people are interested

A broccoli-derived compound studied in cellular-defence signalling. Formulation and conversion strongly affect measured exposure, but exposure is not efficacy and no human trial shows longer lifespan or validated healthspan.

Outcome map

One ingredient. Different questions.

Evidence can be stronger for a specific marker or population and weaker for a broader promise. Each row answers a separate question.

  1. 01

    Human lifespan or validated healthspan

    No completed human intervention reviewed tested and demonstrated longer lifespan or an improvement in validated healthspan.

    Evidence level E
  2. 02

    Active-myrosinase urinary recovery

    One direct crossover showed greater urinary metabolite recovery with verified active myrosinase under exact single-dose conditions; this is exposure, not efficacy.

    Evidence level B
  3. 03

    Higher recovery as clinical benefit

    A higher urinary exposure proxy cannot establish a health benefit, validate another formulation or prove finished-product equivalence.

    Evidence level E
  4. 04

    Prediabetes fasting-glucose signal

    One modest surrogate result exists, but protocol and analysis changes, attrition, a null HbA1c result and no clinical endpoint limit generalization.

    Evidence level C
  5. 05

    Disease prevention or treatment

    The reviewed evidence does not establish prevention or treatment of diabetes, cancer, infection, autism, schizophrenia or other disease.

    Evidence level E
  6. 06

    Universal or long-term safety

    Recurrent gastrointestinal effects and heterogeneous short studies do not establish universal, long-term or interaction-free safety.

    Evidence level E
Library trackResearch Radar
Last reviewed22 Aug 2026
Guide scopeIngredient research only
01

How it may work

A broccoli-derived isothiocyanate studied in cellular defence signalling. Glucoraphanin precursor, active myrosinase, preformed sulforaphane and direct stabilized formulations are not interchangeable, and urinary recovery is an exposure proxy rather than a clinical benefit.

02

What people have studied

Formulation-specific crossover studies show that verified active myrosinase and preformed sulforaphane can increase urinary metabolite recovery relative to glucoraphanin alone. Clinical evidence remains outcome-specific and largely limited to modest surrogates, exploratory or mixed rating-scale findings and informative null trials. No completed human intervention demonstrates longer lifespan or validated healthspan.

03

What to consider

Concentrated formulations can cause gastrointestinal effects, and exact source, conversion, stability and dose matter. Small, selected and heterogeneous trials do not establish universal, long-term or interaction-free safety.

04

Local pathway

This science review does not establish a Thailand market route. Ingredient source, formulation and finished-product status require separate official confirmation.

Sources + indexes

See where the explanation comes from.

Open the linked research and official records behind this guide. Early topics may begin with a research index while stronger sources are added.

  1. 01Active-myrosinase formulation crossover ↗
  2. 02Preformed sulforaphane versus glucoraphanin crossover ↗
  3. 03Stabilized direct SFX-01 phase I study ↗
  4. 04Prediabetes randomized trial ↗
  5. 05Pollutant-metabolite randomized trial ↗
  6. 06COPD randomized trial ↗
  7. 07Thai FDA food entrepreneur portal ↗
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Sulforaphane — CELLIVITY Science Library